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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MELK
All Species:
26.36
Human Site:
Y267
Identified Species:
41.43
UniProt:
Q14680
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14680
NP_055606.1
651
74642
Y267
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
Chimpanzee
Pan troglodytes
XP_001168921
651
74605
Y267
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
Rhesus Macaque
Macaca mulatta
XP_001115076
651
74642
Y267
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
Dog
Lupus familis
XP_538730
651
74149
Y267
H
P
W
I
M
H
D
Y
N
C
P
V
E
W
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q61846
643
72695
W262
R
N
L
L
N
H
P
W
V
M
Q
D
Y
S
C
Rat
Rattus norvegicus
P54645
559
63955
E194
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509217
655
73776
Y269
H
P
W
M
V
Q
S
Y
V
C
P
V
E
W
Q
Chicken
Gallus gallus
NP_001026680
657
74208
Y269
H
P
W
L
M
Q
G
Y
S
D
A
V
Q
W
Q
Frog
Xenopus laevis
NP_001081569
651
74289
Y269
H
P
W
L
M
H
G
Y
S
C
P
V
E
W
Q
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
I323
D
P
E
F
D
R
L
I
V
E
C
E
Q
V
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395000
606
68302
Q241
S
S
S
K
K
L
I
Q
A
M
L
Q
I
D
P
Nematode Worm
Caenorhab. elegans
NP_001023420
703
79966
Y269
H
D
W
L
N
H
K
Y
T
Q
P
V
K
W
N
Sea Urchin
Strong. purpuratus
XP_781767
971
109658
F543
H
P
W
V
V
Q
A
F
G
S
P
V
D
W
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q2V452
441
50581
V75
L
I
K
H
P
N
V
V
Q
L
Y
E
V
M
A
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
I257
L
P
F
D
D
E
S
I
P
V
L
F
K
N
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.4
91.7
N.A.
83.4
29.6
N.A.
70.8
61.7
66.2
20.2
N.A.
N.A.
39.9
37.9
32.7
Protein Similarity:
100
99.5
97.5
95.8
N.A.
90.3
47.4
N.A.
80.1
75.9
80.3
34.1
N.A.
N.A.
55.7
56
45.5
P-Site Identity:
100
100
100
86.6
N.A.
0
6.6
N.A.
66.6
60
66.6
6.6
N.A.
N.A.
0
40
46.6
P-Site Similarity:
100
100
100
86.6
N.A.
13.3
6.6
N.A.
80
80
80
26.6
N.A.
N.A.
0
53.3
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.8
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
7
7
0
7
0
7
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
20
7
0
0
0
7
% C
% Asp:
7
7
0
7
14
0
27
0
0
7
0
7
7
7
0
% D
% Glu:
0
0
7
0
0
7
0
7
0
7
0
14
40
0
7
% E
% Phe:
0
0
7
7
0
0
0
7
0
0
0
7
0
0
0
% F
% Gly:
0
0
0
0
0
0
14
0
7
0
0
7
0
0
0
% G
% His:
60
0
0
7
0
27
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
27
0
0
7
14
0
7
0
0
7
0
7
% I
% Lys:
0
0
7
7
7
0
7
0
0
0
0
0
14
0
7
% K
% Leu:
14
0
7
27
0
7
7
0
0
7
14
0
0
7
0
% L
% Met:
0
0
0
7
40
0
0
0
0
14
0
0
0
7
0
% M
% Asn:
0
7
7
0
14
7
0
0
27
0
0
0
0
7
7
% N
% Pro:
0
74
0
0
7
0
14
0
7
0
54
0
0
0
7
% P
% Gln:
0
0
0
0
0
40
0
7
7
7
7
7
14
0
47
% Q
% Arg:
7
0
0
0
0
7
0
0
0
0
0
0
7
0
0
% R
% Ser:
14
7
7
0
0
0
14
0
14
7
7
0
0
7
0
% S
% Thr:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% T
% Val:
0
0
0
7
14
0
7
7
27
7
0
60
7
7
0
% V
% Trp:
0
0
60
0
0
0
0
7
0
0
0
0
0
60
0
% W
% Tyr:
0
0
0
7
0
0
0
54
0
20
7
0
7
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _